Possible involvement of tachykinin receptors in tachykinin-induced skin inflammation in mice
نویسندگان
چکیده
منابع مشابه
Targeting tachykinin receptors in neuroblastoma
Neuroblastoma is the most common extracranial tumor in children. Despite aggressive multimodal treatment, high-risk neuroblastoma remains a clinical challenge with survival rates below 50%. Adding targeted drugs to first-line therapy regimens is a promising approach to improve survival in these patients. TACR1 activation by substance P has been reported to be mitogenic in cancer cell lines. Tac...
متن کاملTachykinin receptors and airway pathophysiology.
The mammalian tachykinins (TKs), substance P and neurokinin A, are present in sensory nerve fibres in the upper and lower airways of various mammalian species, including humans. TKs are released from these afferent nerves in an "efferent" mode at peripheral level, especially in response to irritant stimuli. TKs exert a variety of biological effects (bronchoconstriction, plasma protein extravasa...
متن کاملPharmacology and Function of Tachykinin Receptors
The existence of SP was described in the 1930s by Von Euler and Gaddum in mammals, and tachykinin peptides were identified and sequenced by Erspamer in non-vertebrated (eledoisin) and then in nonmammalian species (physalaemin). In the 1960s Lembeck continued Von Euler and Gaddum’s studies, describing the effects of SP and other tachykinins in the central nervous system (CNS) and peripheral prep...
متن کاملThe effect of fluoxetine on thermal hyperalgesia in STZ-induced diabetic mice: possible involvement of 5-HT1/2 receptors
Diabetic neuropathic pain, an important micro vascular complication in diabetes mellitus, has been recognized as one of the most difficult types of pain to treat. Lack of understanding of etiology involved, inadequate relief, development of tolerance and potential toxicity of classical anti-nociceptive agents warrants the investigation of newer agents to relieve this pain. The aim of the presen...
متن کاملThe effect of fluoxetine on thermal hyperalgesia in STZ-induced diabetic mice: possible involvement of 5-HT1/2 receptors
Diabetic neuropathic pain, an important micro vascular complication in diabetes mellitus, has been recognized as one of the most difficult types of pain to treat. Lack of understanding of etiology involved, inadequate relief, development of tolerance and potential toxicity of classical anti-nociceptive agents warrants the investigation of newer agents to relieve this pain. The aim of the presen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1998
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)40772-5